Poststroke Angiogenesis, Pro

Poststroke angiogenesis, pro: making the desert bloom.

A ngiogenesis, in which existing blood vessels give birth to new capillaries, is a widely conserved response to hypoxia, including ischemic hypoxia. Angiogenesis occurs in peri-infarct regions of human brain after stroke, as documented by histological and immunohistochemical studies of postmortem tissue. Among many questions that might be asked about angiogenesis and stroke, the most apposite i...

Poststroke angiogenesis, con: dark side of angiogenesis.

A ngiogenesis, the regrowth of new blood vessels, occurs after stroke 1 and thus raises hopes that this regeneration is beneficial for patients with stroke. There is no doubt, that the restoration of blood supply, providing oxygen and nutrients to the ischemic brain tissue, is beneficial for stroke recovery. However, it is debated, whether angiogenesis truly contributes to improved recovery. Th...

Poststroke angiogenesis: blood, bloom, or brood?

Positron emission tomography imaging of poststroke angiogenesis.

BACKGROUND AND PURPOSE Vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) play important roles during neurovascular repair after stroke. In this study, we imaged VEGFR expression with positron emission tomography (PET) to noninvasively analyze poststroke angiogenesis. METHODS Female Sprague-Dawley rats after distal middle cerebral artery occlusion surgery were subjected to ...

Anti-angiogenesis or pro-angiogenesis for cancer treatment: focus on drug distribution.

Enhancing chemotherapy delivery to tumors, improving tumor growth control, reducing metastasis, and increasing survival are all critical objectives of improved cancer therapy. One of the obstacles to the success of anticancer therapies is related to the inefficient distribution of drugs to tumor cells. To be effective, chemotherapeutics must reach a concentration in cancer cells that is suffici...